Polycystic ovary syndrome (PCOS) inheritance!
The inheritance of polycystic ovary syndrome (PCOS) is influenced by both genetic and nongenetic factors, including maternal obesity, androgen levels, and gestational diabetes.
Environmental conditions prior to conception and during pregnancy influence the transmission of PCOS via fetal, placental, and germ cells.
Targeted treatment of hyperandrogenism and improvement of placental function can reduce maternal and fetal risks and break the cycle of disease transmission.
A better understanding of the transgenerational epigenetic mechanisms of PCOS is needed to manage the disease across generations.
Germ cells can transmit PCOS independently, suggesting that both men and women could pass the disease on to their offspring.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00324-2
