Osteochondral regeneration using 3D bioprinting

Synchronous osteogenesis and chondrogenesis for the reconstruction of osteochondral (OC) defects is challenging.

The authors developed  a bioprinting technology using anisotropic bicellular living hydrogels (ABLHs) to simultaneously embed articular cartilage progenitor cells (ACPCs) and bone mesenchymal stem cells (BMSCs) in stratified layers at room temperature with high cell viability.

They show that ABLHs promoted osteochondral regeneration by fulfilling osteogenesis and chondrogenesis. They also demonstrate that ABLHs exhibited satisfactory synchronous regeneration of cartilage and subchondral bone in vivo. 

The authors confirm cartilage-bone-vessel crosstalk that could lead to the reconstruction of the osteochondral interface.

https://www.cell.com/the-innovation/fulltext/S2666-6758(23)00170-4

https://sciencemission.com/3D-bioprinted-ABLHs-boost-osteochondral-regeneration