Pediatric precision neuro-oncology!
Pediatric brain tumors have specific clinical and molecular features, and only a small fraction of patients benefit from current precision oncology approaches.
Functional precision medicine combines molecular profiling with drug sensitivity testing of patient-derived tumor models to uncover actionable vulnerabilities.
Patient-derived models generated from limited biopsy material enable clinically relevant pharmacological highthroughput screening.
Integrating drug sensitivity data with molecular profiling facilitates drug repurposing and personalized combination therapies to ultimately improve patient outcomes.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00129-9
