Neural stem cell exosomes to treat retinal ischemia-reperfusion injury
Retinal ischemia-reperfusion injury (RIRI) leads to neuronal damage of the retina and causes visual impairment in patients.
The authors had clinically observed significant decrease in catalase activity correlates with increased hydrogen peroxide (H2O2)-mediated oxidative stress that is primarily localized to the outer nuclear layer (ONL) situated in the posterior segment of the retina.
The researchers developed a polylysine (K10)-decorated and catalase-expressing exosome (CataKNexo).
The authors show that CataKNexo reaches the ONL and prevents H2O2-induced retinal cell death, exerts neuroprotection, and restores retinal function in RIRI mice and Bama miniature pigs.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00125-9
https://sciencemission.com/Catalytic-neural-stem-cell-exosomes
