RNA dysregulation in aging and neurodegeneration
Physiological aging results in widespread changes in RNA processing, degradation, modifications, and translation in the nervous system.
Corresponding changes in RNA-binding protein regulatory networks and aberrant ribonucleoprotein granule dynamics contribute to RNA dysregulation.
Age-related RNA dysregulation may predispose neurons to declining function and neurodegeneration.
Understanding how aging reshapes RNA regulatory networks will reveal new therapeutic opportunities for neurodegenerative disease.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00164-9
https://sciencemission.com/RNA-dysregulation-as-a-determinant-of-aging-and-NDD
