RNA processing and mechanotransduction interplay!

Cells respond to mechanical changes in surrounding environment through a process called mechanotransduction that involves mechanosensor detector and the conversion of mechanical stimulus into a biochemical signal, which can ultimately control the expression of genes.

The researchers in this review discuss links between mechanotransduction and RNA processing, with a focus on alternative splicing and polyadenylation.

They also describe how genes encoding mechanosensory proteins are alternatively spliced and alternative splicing might impact isoform functions and the role of mechanical forces on alternative splicing and polyadenylation processes.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00946-5

https://sciencemission.com/RNA-processing-and-mechanotransduction