Regulating sensory and affective aspects of pain
Neural mechanisms of pain sensitivity remain elusive.
The researchers demonstrate that discrete populations of anterior paraventricular nucleus (PVA) glutamatergic PVAVgluT2 neurons are engaged in sensory and affective pain processing.
The authors identify the segregation of PVAVgluT2 projections to the bed nucleus of the stria terminalis (BNST) and nucleus accumbens (NAc), each influencing specific aspects of pain-like behavior highlighting the important role of PVA neurons and their divergent projections in functional specialization.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01297-X
https://sciencemission.com/Regulating-sensory-and-affective-aspects-of-pain
