Role of gut microbiota in vagotomy induced mastitis in mice
Gut microbiota dysbiosis has been linked to the development of mastitis. Although the vagus nerve and gut microbiota interaction regulates disease development, the role of vagus nerve participation in pathogenesis of mastitis is not known.
The researchers demonstrate that vagotomy induces disturbances of gut microbiota driven tryptophan metabolism, decreases circulating 5-hydroxyindole acetic acid (5-HIAA) levels, disrupts the blood-milk barrier, and induces mastitis in mice.
Exogenous supplementation of 5-HIAA activates the aryl hydrocarbon receptor (AhR) and thereby inhibits the NF-kB pathway to alleviate vagotomy-induced mastitis in mice.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00914-8
