Roles of ECSIT in immunity and tumorigenesis
Evolutionary conserved signaling intermediate in toll (ECSIT) is an evolutionary conserved protein that displays dual functions in the cytosol and mitochondria.
ECSIT is an essential Complex I assembly protein required for mitochondrial function.
ECSIT has multiple roles in regulating immune responses by serving as a conduit between the mitochondria and cytosolic signaling pathways.
Recent findings suggest that ECSIT has a key role in tumorigenesis by regulating the levels of key metabolites in the cell.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00189-2
https://sciencemission.com/Emerging-roles-of-ECSIT-in-immunity-and-tumorigenesis
