Mast cell mediated processes for inflammatory signal relay
Role of neutrophil immune cells in allergic conditions are not known,
The authors show that during allergen challenge, degranulating mast cells (MCs) re-route and trap living neutrophils in vivo, resulting in functional and metabolic alteration of the mast cell and the acquisition of neutrophilic features.
Mechanistically, they also demonstrate that after MC intracellular trap (MIT) formation, neutrophils die, but their undigested material remains inside MC vacuoles over days. MCs benefit from MIT formation, increasing their functional and metabolic fitness. Additionally, they are more pro-inflammatory and can exocytose active neutrophilic compounds with a time delay (nexocytosis), eliciting a type 1 interferon response in surrounding macrophages.
