Sleeping less with a SIK3 mutation
Reduced daily sleep duration in human subjects is a condition called natural short sleep (NSS) and people with NSS require only 4–6 h of sleep per night to function efficiently without negative health effects.
The researchers recently found an NSS mutation (N783Y) in the salt-induced kinase 3 (SIK3) gene, shedding new light on the genetic basis of human sleep regulation.
This mutation in a mouse model leads to decreased SIK3 activity and altered global protein phosphorylation profiles, especially for synaptic proteins. The researchers also identified several sleep-related kinase alterations triggered by the SIK3-N783Y mutation, including changes in protein kinase A and mitogen-activated protein kinase.
https://www.sciencedirect.com/science/article/pii/S016895252500157X
