Non-typhoidal Salmonella disrupts germinal centre

Salmonella enterica serovar Typhimurium (STm) causes millions of global infections annually, typically resulting in self-limiting gastroenteritis. It can lead to invasive non-typhoidal salmonellosis (iNTS), a life-threatening systemic disease in vulnerable individuals. 

No licensed human vaccine exists for STm, partly because conventional subunit vaccines lack mucosal efficacy. More complex live-attenuated and outer membrane vesicle (OMV)- based mucosal vaccines are promising but face greater clinical safety and regulatory hurdles.

STm infection perturbs germinal centre B (GCB) cell responses, impairing antiSTm immunity and other ongoing GCB reactions. The impact on B cell memory and whether live or OMV vaccine candidates may induce it remains unstudied.

GCB perturbation may also be triggered by pathogens other than STm, warranting broader investigation.

https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00226-1

https://sciencemission.com/BH3-mimetic-therapies