Sensory signals for nausea
Nausea is a protective interoceptive response that integrates external sensory cues, visceral signals, and psychological states across diverse clinical contexts.
Most nausea signals are likely detected through the vagus nerve and the area postrema – which convey signals from the gut and blood circulation to central nausea circuits.
Different physiological and pathological signals activate the vagus nerve and the area postrema through distinct molecular triggers, such as gut-derived hormones, neurotransmitters, and fetal derived factors.
Immune signals such as inflammatory cytokines are increasingly recognized as upstream contributors to nausea in allergic, inflammatory, and cancer cachexia conditions.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00170-5
