Sepsis therapy using multimodal hybrid nanozymes
Treating sepsis is a challenging process due to its complexity and require better treatment options with high therapeutic efficacy.
The researchers developed Ce-baicalein nanozymes (Ce-BE NZs) with broad spectrum antibacterial and redox enzyme-mimicking activities. Ce-BE NZs also corrected immune dysregulation, reduced liver injury, and extend survival in sepsis models.
These CeBE NZs showed multi-target therapeutic efficacy by inhibiting ferroptosis and mitigating mitochondrial dysfunction in sepsis models, thus offering a strategy for the treatment of sepsis and other infectious diseases.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00614-7
