Serotonin transporter role in cancer immunity
Identifying the check points that hinders antitumor T cell responses helps in cancer immunotherapy.
The researchers show induction of serotonin transporter (SERT) in tumor-infiltrating CD8 T cells. SERT inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin.
SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.
https://www.cell.com/cell/fulltext/S0092-8674(25)00502-1
https://sciencemission.com/Serotonin-transporter-inhibits-antitumor-immunity
