The nucleus accumbens neurons control feeding and energy homeostasis

The nucleus accumbens (NAc) also controls appetite and satiety, in addition to hypothalamus neuronal circuits but specific neuronal subtypes of the NAc that are involved and the signals that coordinate to regulate feeding remain unclear.

The researchers demonstrate neuron subtypes of the NAc shell (NAcSh) and define a dopamine receptor D1-expressing and Serpinb2-expressing subtype controlling food consumption in male mice.

They also show that NAcShSerpinb2→LHLepR projection controls refeeding and can overcome leptin-mediated feeding suppression and NAcSh Serpinb2+ neuron ablation reduces food intake and upregulates energy expenditure, resulting in reduced bodyweight gain.

https://www.nature.com/articles/s42255-024-01100-0

https://sciencemission.ayurmatrika.com/A-subset-of-dopamine-receptor-expressing-neurons-in-the-nucleus-accumbens-controls-feeding-and-energy-homeostasis