Role of liver in post-cardiac arrest brain injury

The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ischemia.

The researchers show that the frontal lobe infarct area and temporal lobe immune cell adhesion were increased in the ischemic brains in the presence of concurrent hepatic ischemia.

Ex vivo, presence of a functioning liver improved neuronal viability, cytoarchitecture, and electrocortical activity post-CA brain injury.

Transcriptomics and metabolomics analyses suggest that the liver protects from post-CA brain injury by increased production of ketone bodies.

https://www.embopress.org/doi/full/10.1038/s44321-024-00140-z

https://sciencemission.ayurmatrika.com/Liver-protects-neuron-viability-and-electrocortical-activity-in-post-cardiac-arrest-brain-injury