Thyroid hormone remodels exploratory behavior
The direct action of thyroid hormone on the cortical circuits of male mice integrates exploratory behaviors with whole-body metabolism.
The authors show that thyroid hormone, T3 directly activates cell-type-specific transcriptional programs in adult cortex.
They also demonstrate that T3-regulated gene programs (TRGPs) alter excitatory and inhibitory synaptic transmission and drive changes in exploratory behaviors and decision-making via whole-body metabolism.
