Lysosomal regeneration after damage

How the lysosomes are stored after damage is not clear. After damage, lysosomes undergo extensive ubiquitylation that helps restore lysosomal function. 

The researchers show that deubiquitinating enzyme ATXN3 is recruited to damaged lysosomes.

ATXN3 with its partner p97 targets proteins modified with K48-K63 branched ubiquitin chains on proteins including LAMP2 and processes them to facilitate degradation by microautophagy.

ATXN3 thus contributes to regeneration of functional lysosomes.

https://www.embopress.org/doi/full/10.1038/s44318-025-00517-x

https://sciencemission.com/ATXN3-regulates-lysosome-regeneration