The mechanism of  acetaminophen action!

The mechanism of action of acetaminophen (paracetamol), a common analgesic, is not yet clear. 

The study shows that acetaminophen counterintuitively inhibits diacylglycerol lipase α  (DAGLα), but not DAGLβ, reducing the production of the endocannabinoid 2-arachidonoyl glycerol.

This suggests a novel pain-relieving mechanism through cannabinoid 1 receptors.

These findings offer new insights into acetaminophen’s action, challenging traditional models of its analgesic effects.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00212-5

https://sciencemission.com/Acetaminophen-inhibits-diacylglycerol-lipase