How brain mediates exercise-induced improvement in endurance
Exercise remodels skeletomuscular, cardiovascular, metabolic, endocrine systems and thus provides physiological benefits.
The researchers observed that in mice, repeated exercise potentiates the activity of ventromedial hypothalamic SF1-expressing neurons.
They also demonstrate that exercise training increases the intrinsic excitability and density of excitatory synapses on SF1 neurons and SF1 neural activity is required for mice to achieve the endurance benefits of exercise.
Inhibition of SF1 neuron output blocks endurance gains and metabolic improvements that result from exercise training. Conversely, stimulation of SF1 neurons following exercise enhances gains in endurance.
https://www.cell.com/neuron/fulltext/S0896-6273(25)00989-4
