Predicting resilience to fructose induced hepatic steatosis
Liver diseases like metabolic-dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and cancers are associated with the excessive intake of dietary fructose but the host factors involved in the disease vulnerability is not well documented.
The researchers identify a blood glycerate surge after an oral fructose tolerance test as the predictor of an individual’s resilience to fructose-induced fatty liver.
The authors believe such fructose clearance by the small intestine is linked to a weaker induction of hepatic de novo lipogenesis and steatosis upon chronic fructose exposure across strains.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00209-8
