Tug-of-war between cancer and immune cells for mitochondria
Horizontal mitochondrial transfer and the tug-of-war between cancer cells and immune cells
Both cancer and immune cells commonly share a metabolic dependency on functional mitochondria.
Cancer cells can acquire mitochondria from immune cells by means of horizontal mitochondrial transfer, leading to immune cell exhaustion.
Horizontal mitochondrial transfer can be harnessed to direct mitochondria toward immune cells, thereby enhancing their cancer cell-killing capabilities.
The tug-of-war between cancer and immune cells will decide the outcome of the competition between the two cell teams for mitochondria.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00126-3
https://sciencemission.com/Horizontal-mitochondrial-transfer
