Sex-sensitive psychedelic pharmacology in serotonergic signaling

Sex and endocrine state may shape psychedelic target engagement and treatment response. 

Dose, stress, and context modulate sex sensitive psychedelic effects.

Sex differences in serotonergic signaling likely reflect state-dependent pharmacological modulation.

Raphe circuitry, receptor signaling, serotonin transporter function, and hypothalamic–pituitary–adrenal-axis mechanisms may shape signal integration.

Plasticity and neuroimmune pathways may contribute to the durability of therapeutic outcomes.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(26)00175-6

https://sciencemission.com/Sex-sensitive-serotonergic-signaling