How exercise protects against cancer?
Anticancer effects of exercise remain poorly understood.
recently identified an exercise-induced, muscle-derived extracellular vesicle (EV)-associated miR, miR-29a-3p, as a key player in the potential benefits of exercise against nonsmall-cell lung carcinoma (NSCLC).
The authors show that that voluntary exercise sensitizes immunotherapy in mouse models and patients with cancer by releasing muscle-derived miR-29a-3pcontaining EVs.
These EVs accumulate in tumor tissue and inhibit collagen components, leading to an inflammatory tumor immune microenvironment and sensitizing immunotherapy.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01048-9
https://sciencemission.com/exercise-sensitizes-cancer--immunotherapy
