How foam cell-derived exosomes exacerbate ischemic white matter injury?
The pathomechanism of atherosclerosis (AS) as an independent risk factor for vascular cognitive impairment remains unclear.
The researchers find that macrophage derived foam cells in atherosclerotic plaques exacerbate ischemic by targeting microglia.
Exosomes transmit redox imbalance, mitochondrial dysfunction, and metabolic defects to microglia via the miR-101-3p-Nrf2-Slc2a1 axis driving vascular cognitive impairment (VCI) progression after atherosclerosis.
Anti-miR-101-3p or activation of Nrf2, both genetically and pharmacologically, could antagonize AS exosomes and ameliorate VCI.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00219-0
https://sciencemission.com/The-foam-cell-derived-exosomes-exacerbate-ischemic-white-matter-injury
