Visualizing first steps of tumorigenesis
Intravital microscopy, tissue clearing, and spatial transcriptomics are emerging technologies that enable the mechanistic dissection of tumor initiation in vivo.
Mutant clone fate is governed by multiscale interactions, including local competition, niche signals, and systemic factors.
Clonal cooperation enables early lesion formation by compensating for mutation-specific deficiencies.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00038-5
