TLR7/8 agonist-complexed graphene oxide nanosheets engineer glioblastoma microenvironment
The tumor microenvironment of aggressive brain tumors is immunosuppressive, which can support their growth and progression.
The researchers show that through delivery of graphene oxide (GO) nanosheets complexed with an immunostimulatory agonist, they can reprogram the immune microenvironment of glioblastoma and suppress tumor growth.
The authors demonstrate that GO effectively delivered R848 (TLR7/8 agonist), enhancing tumor-associated macrophages and microglia (TAMM) reprogramming from an M2-like to an M1-like state in vitro. I
In a syngeneic mouse model, GO:R848 treatment significantly increased M1-like markers (MHCII, CD86, and TNF-α), reduced M2-like markers (ARG1 and YM1), increased T cell infiltration, and inhibited tumor progression.
www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(24)00656-8
