Human nucleus basalis of Meynert organoids (hnbMOs) development!
The nucleus basalis of Meynert (nbM) regulates cortical function and cognition. nbM-cortical cholinergic pathway dysfunction is implicated in neurodegenerative and neurodevelopmental disorders, including Alzheimer’s disease (AD) and Down syndrome (DS).
The researchers report a method for creating human nbM organoids (hnbMOs) from human pluripotent stem cells (hPSCs) containing cholinergic projection neurons that form functional connections with the cortex assembloids (hCOs) and form synaptic connections.
The authors also observed a human-specific cholinergic projection system in transplanted assembloids.
This work provides a model to investigate nbM circuits and cholinergic dysfunction in neurological disorders.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00372-8
