A xeno-free human iPSC-derived prostate organoid platform

Current prostate organoid  models lack reproducibility, scalability, and experimental manipulation.

 The researchers developed a defined, xeno-free, scaffold-free human iPSC-derived prostate organoid platform supporting epithelial and stromal differentiation.

Organoids generated through monoculture or modular co-culture approaches enable compartment specific genetic manipulation and recapitulate key features of prostate tissue organization, providing a reproducible platform for developmental and disease studies.

https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(26)00239-0

https://sciencemission.com/A-xeno-free-human-iPSC