Multipotent intermediate progenitors!
Cortical radial glia generate both neurons and macroglia via intermediate progenitors.
Single-cell RNA sequencing and lineage tracing in mice and humans reveal multipotent and glial-restricted intermediate progenitors after the gliogenic switch.
A shared intermediate progenitor generates cortical macroglia and a subpopulation of interneurons, which the authors term multipotent intermediate progenitor cells.
Distinct transcriptional programs and developmental signals, including NOTCH, ERK, and sonic hedgehog, govern the generation of multipotent intermediate progenitor cells and their downstream progeny.
Multipotent intermediate progenitor cell transcriptional signatures and specification programs are recapitulated in gliomas, positioning multipotent intermediate progenitor cells as putative tumor-initiating cells.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00051-2
