mRNA decay pathways are linked to intrinsically disordered regions of RNA binding proteins
RNA-binding proteins typically have a structured RNA-binding domain flanked by stretches of low-sequence complexity that are intrinsically disordered.
The intrinsically disordered regions of an RNA-binding protein recruit different messenger RNA decay enzymes that are the effectors of degradation, resulting in the assembly of decay-competent ribonucleoproteins.
Intrinsically disordered regions allow flexibility in protein–protein interactions in terms of strength and stoichiometry, allowing the RNA-binding protein to mediate multiple interactions, often concomitantly with many factors, thereby expanding its functional repertoire.
The interaction network mediated by intrinsically disordered regions allows for the intersection of pathways regulating gene expression, such as messenger RNA decay and translational repression.
The intrinsically disordered region-driven interaction network is dynamic and subject to spatial and temporal regulation, as well as post-translational modifications of the RNA-binding protein.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(26)00178-7
https://sciencemission.com/Intrinsically-disordered-regions-23597
