How mechanical cues impact neural stem cell lineage decisions
In the developing human brain mechanical cues vary across regions and along differentiation trajectories.
The researchers demonstrate that the mechanical manipulations of human brain organoids shifts the balance between proliferation and differentiation of neural stem cells.
They show that the protein levels of the neural stem cell controlling factor SOX2 are regulated by mechanical manipulation.
In addition, mechanical manipulation impacts on molecular programs governing early patterning events and cellular metabolism.
https://link.springer.com/article/10.1038/s44319-026-00719-2
