Targeting mechanotransduction in barrier organs
Mechanical forces regulate growth, inflammation, and fibrosis in barrier organs, including the skin, lung, and cornea.
Piezo/transient receptor potential vanilloid 4/integrin–Yes-associated protein forms conserved mechanotransduction hubs, linking mechanical cues to immune and metabolic reprogramming.
Emerging platforms—organ-onchip, ex vivo tissue slices, and 3D printing—facilitate preclinical study of mechanosensing-based interventions for inflammatory and fibrotic conditions.
Cross-organ convergence of these pathways supports translational strategies using targeted drugs, stiffness-tuned biomaterials, and mechanotherapies to treat fibrosis, chronic wounds, and related pathologies.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(26)00038-9
