Crosstalk between the metabolome and the epigenome

The cells adapt to the environmental changes by incorporating the altered metabolic information into the transcription process and thus Chromatin act as a sensor for fluctuating intracellular metabolites.

The researchers in this review discuss the growing list of chromatin-associated metabolites that are derived from diverse sources and highlight the mechanisms by which metabolic enzyme activities shape the chromatin structure and modifications.

They also discuss the technologies that facilitate the study of epigenome-metabolome interplay.

The importance of metabolites in the regulation of chromatin has significant implications for the evolution, function, and therapeutic targeting of the epigenome.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)01007-4

https://sciencemission.com/Metabolism-driven-chromatin-dynamics