How mitochondria regulates ferroptosis

Mitochondria are central regulators of ferroptosis, integrating iron metabolism, reactive oxygen species production, and lipid homoeostasis. 

Ferroptosis may contribute to tissue specific pathology in primary mitochondrial diseases.

Mitochondrial lipid composition and polyunsaturated fatty acid distribution set thresholds for ferroptosis sensitivity.

Iron–sulfur cluster biogenesis and iron partitioning control labile iron pools and ferroptotic vulnerability.

Coenzyme Q biosynthesis and intracellular trafficking link mitochondrial function to global ferroptosis defence systems.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(26)00150-5

https://sciencemission.com/Mitochondria-setting-the-stage-for-ferroptosis