Mechanism of multiple functions of HMGB1
Fuzzy interactions mediated by intrinsically disordered regions (IDRs) allow dynamic regulation and interaction diversity across various cellular processes relevant to biological activity.
High mobility group box 1 (HMGB1) protein, a multitasking molecule involved in diverse intracellular and extracellular processes and several human diseases, is intrinsically fuzzy and forms fuzzy complexes.
The authors delve into how the conformational malleability of HMGB1 provided by its IDRs underpins its ability to engage with multiple partners and perform diverse functions across different cellular compartments and conditions. Fuzziness appears to be essential in modulating HMGB1 diverse functions.
Understanding HMGB1 functions through the lens of fuzziness provides a novel perspective.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00190-2
