A neural circuit mediating anxiety-like behaviors
Feelings of unease and worried thoughts are characteristics of anxiety with sweating and dizziness feelings. But the neural circuits underlying anxiety are not yet clear.
They also report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states. They also show that MeATac1 neurons regulate anxiety-like behaviors in mice bidirectionally.
The researchers show that GABAergic neurons in the ventral tegmental area (VTA)GABA→MeATac1→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) circuit contribute to anxiety-like behavior in mice.
https://www.embopress.org/doi/full/10.1038/s44319-025-00528-z
https://sciencemission.com/A-MeA-Tac1-neural-circuit-mediates-anxiety
