The neuroimmune nexus in Alzheimer’s disease
Neuroinflammation had been well documented in Alzheimer’s disease (AD).
Current evidence suggest that dysregulation in cyclic GMP-AMP synthase (cGAS)- STING pathway may culminate in AD-related neuroinflammation and neurodegeneration.
In addition, release of mitochondrial DNA (mtDNA) into the extramitochondrial space from mitochondrial damage in AD may activate CGAS-STING pathway leading to an imbalance in immune homeostasis.
In this review, the researchers focus on the mechanisms of mtDNA release during stress and the activation of the cGAS-STING pathway and its role in AD.
They also discuss the development of therapeutic drugs to target the neuroinflammation.
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-025-00815-2
