Mechanisms of whole-genome doubling in cancer evolution
Whole-genome doubling (WGD) has recently emerged as a frequent and ongoing occurrence that drives cancer evolution.
The molecular bases for the causes and effects of WGD are being rapidly uncovered.
These molecular mechanisms are revealing vulnerabilities that can be targeted for cancer treatment.
Therapies that target WGD have great potential to halt disease progression and prevent acquired drug resistance.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00252-3
