A TBK1-independent primordial function of STING in lysosomal biogenesis
The researchers discover TFEB/TFE3 as evolutionarily ancient effectors of the cGAS-STING DNA-sensing innate immune pathway.
TFEB/TFE3 activation via the channel of STING integrates cytosolic DNA sensing, a general cellular stress-sensing mechanism, with lysosomal biogenesis and autophagy upregulation, conserved and general strategies for host defense and stress clearance.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00703-2
