Gelatin hydrogels support development and maturation of iPSC-derived cortical organoids
Neural organoids are widely used models of the developing brain.
In this work, the researchers compare the development of organoids in a commercial biomaterial (Matrigel) versus a peptide-functionalized gelatin matrix (GelMA-Cad).
The biomimetic N-cadherin peptide on GelMA-Cad is shown to reinforce neural fate and aid maturation relative to Matrigel.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01225-7
