Aberrant phase separation drives membranous organelle remodeling and tumorigenesis
Various numerous cellular functions require membrane remodeling.
It is not clear if liquid-liquid phase separation (LLPS)-mediated membrane-remodeling functions in live cells and what role it plays in specific bioprocesses.
The researchers. reveal how membrane anchored fusion proteins, generated by chromosome translocation, undergo phase separation to remodel endomembranes.
They dissect its biological implications, providing insights into the interplay between phase separation and membrane remodeling in live cells.
The authors show that FUS-CREB3L2 drives endoplasmic reticulum (ER) remodeling via phase separation to form COPII-like compartments, which promote RIP of FUS-CREB3L2, releasing its N terminus from ER, which in turn activates ow-grade fibromyxoid sarcoma (LGFMS)-specific genes in the nucleus.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00304-1
https://sciencemission.com/phase-separation-drives-membranous-organelle-remodeling
