Allosteric antibodies in drug discovery
A novel pharmacology is emerging that enables precise regulation of protein activity through antibody binding to allosteric sites/epitopes, paving the way for a deeper understanding of allosteric regulations of target proteins.
Successful discoveries of allosteric antibodies against previously antibody undruggable targets, such as G protein coupled receptors (GPCRs) or ligand gated ion channels, are shedding light on potential new druggability avenues with antibodies.
Allosteric antibodies are also of interest for small molecules discovery, opening up a new era by integrating the two technologies.
Recent efforts in the fields of computational biology and artificial intelligence (AI) hold promise for integrating allosteric site detection with de novo antibody design, paving the way for efficient allosteric antibody discovery.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00218-9
https://sciencemission.com/Allosteric-antibodies:-a-novel-paradigm-in-drug-discovery
