Neuropathic changes in pancreatic cancer

In pancreatic cancer, local neuropathic changes, such as axonogenesis, neurogenesis, neural remodeling, perineural invasion, and pancreatic neuritis, are frequently encountered. 

Pancreatic cancer can modulate central nervous system functions through specific molecules and cell types, affecting pain sensation and resulting in symptoms like appetite suppression, anorexia, and cognitive decline.

Chemotherapy-induced neuropathy, caused by drugs like oxaliplatin and paclitaxel, involves sensory disorders and neuropathic pain due to ion channel changes, altered neuronal excitability, and gut microbiota influences, impacting quality of life in individuals with pancreatic cancer.

The intricate interplay of sympathetic, parasympathetic, and sensory nerves in pancreatic cancer displays diverse roles in tumor growth and immune modulation, highlighting the potential for targeted therapeutic strategies based on nerve-dependent mechanisms.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00242-X

https://sciencemission.com/neuropathic-changes-in-pancreatic-cancer