Targeting gut microbiota in CDKL5 deficiency disorder
Gastrointestinal (GI) issues and immune dysregulation are common among cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) but the role of gut microbiota is not clearly understood.
The researchers show that CDKL5 deficiency disorder mouse models have an altered gut microbiota composition.
Targeting intestinal microbes through antibiotics improves behavior, visual responses, and microglia phenotype.
Finally, a causal link between the CDKL5 KO microbiota and the observed phenotype is demonstrated through fecal transplantation into WT recipient mice.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00317-1
