Brain health and waste clearance in aging

Waste material from brain is cleared by the fluid flow dynamics to maintain brain health and is regulated by vascular dynamics, the maintenance of perivascular spaces, neural activity during sleep, and lymphatic drainage in the meningeal layers. 

Impairment in the fluid flow regulation and thus cleansing of the waste material during aging may lead to age-associated neurological disorders, including Alzheimer’s and Parkinson’s diseases.

New therapeutics to tackle age-associated neurological decline could be developed by understanding the intricacies of fluid flow regulation in the brain.

https://www.cell.com/neuron/fulltext/S0896-6273(24)00687-1

https://sciencemission.com/Waste-clearance-shapes-aging-brain-health