Capturing RAS oligomerization on a membrane

Mutations in RAS proteins are associated with several human cancers by activating downstream signaling cascades.

RAS oligomers are thought to activate downstream proteins and suppress mutant RAS-driven cancers. Disruption of RAS multimers and membrane localization could be used to target cancer.

However discrepancies in RAS stoichiometries and the indirect methods to detect the RAS dimers has made the field controversial.

Using native mass spectrometry in this study, the researchers capture RAS dimerization on membranes that is directly influenced by lipid composition, posttranslational modifications, nucleotides, and small molecules.

https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(24)00222-6

https://sciencemission.ayurmatrika.com/Two-hearts-beat-as-one:-the-debate-over-RAS-dimers-continues