Therapeutic targeting of senescent cells in the CNS

During aging process and in various disease conditions senescent cells accumulate and negatively impact health and function of multiple systems, including the central nervous system (CNS).

Senotherapeutics to target senescent cells in CNS have been emerging and involve clearing senescent cells. Several senolytics like dasatinib and quercetin have emerged and have been used successfully in the preclinical studies although brain penetrance and potential toxic side efects of CNS-acting senotherapeutics pose challenges for drug development and translation to the clinic.

This Review assesses the potential impact of senotherapeutics for neurological conditions by summarizing preclinical evidence, innovative methods for target and biomarker identifcation, academic and industry drug development pipelines and progress in clinical trials.

https://www.nature.com/articles/s41573-024-01033-z

https://sciencemission.ayurmatrika.com/Therapeutic-targeting-of-senescent-cells-in-the-CNS