Cell death in cancer

Cancer cells are transformed to withstand oncogenic and therapeutic stress and thus evade cell death.

It is necessary to understand cell death programs in order to restore cell death programs in cancer cells. The cell death programs include apoptosis, necroptosis, pyroptosis, ferroptosis, and others.

Non-apoptotic mediated cell death programs can drive inflammatory responses and orchestrate the interplay among tumor, stroma, and immune components, influencing immunotherapy outcomes.

Perturbations in lipid, iron, and redox metabolism leads to ferroptosis, an iron-dependent, lipid peroxidation-driven cell death, lacks a canonical induction signal and arises from.

The researchers in this review discuss the roles of major cell death programs in cancer development, progression.

https://www.cell.com/cell/fulltext/S0092-8674(26)00325-9
https://sciencemission.com/Cell-death-in-cancer